Regulatory T cells (Tregs)

Marker Expression

FOXP3
Expression: +
Localization: intracellular
Required
CD4
Expression: +
Required
TGFβ
Expression: +
Localization: secreted
Analysis strategy: Upon stimulation
Suggested
IL-10
Expression: +
Localization: secreted
Analysis strategy: Upon stimulation
Suggested
CD25 (IL-2RA)
Expression: +
Suggested
CD8a
Expression: -
CD127 (IL-7RA)
Expression: +/-
CD152 (CTLA-4)
Expression: +

CD4 T helper subset that modulates immune responses and maintains tolerance to self-antigens, preventing autoimmunity.