Th1 cells

Marker Expression

  • TBET (TBX21)
    Expression: +
    Localization: intracellular
    Citations:
    Required markerRequired
  • CD4
    Expression: +
    Required markerRequired
  • CD183 (CXCR3)
    Expression: +
    Citations:
    Suggested markerSuggested
  • CD196 (CCR6)
    Expression: -
    Citations:
    Suggested markerSuggested
  • IFNγ (IFNG)
    Expression: +
    Localization: secreted
    Analysis strategy: Upon stimulation
    Citations:
    Suggested markerSuggested
  • IL-2
    Expression: +
    Localization: secreted
    Analysis strategy: Upon stimulation
    Citations:
  • CD8a
    Expression: -

Cell/subset Information

Th1 cells promote immune responses against intracellular pathogens including virus and some bacteria.

Other Notes

Naive CD4+ T cells differentiate into Th1 cells in the presence of IL-12.